Ultramist® Technology

The Ultramist ®
System Therapy

━ The UltraMIST® System Therapy Developed for Evidence-Based Wound Care, Perfect for Multiple Aesthetic Applications
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━ Noncontact, Low-Frequency Ultrasound Therapy Has Been Proven to Expedite Healing.

FDA Approved UltraMIST Therapy has been clinically demonstrated to promote healing across a wide range of chronic and acute wounds. This is what makes UltraMist perfect for multiple Aesthetic Applications. The UltraMIST System delivers low-frequency ultrasound to the treatment site without touching the skin using a fluid (such as saline) in a specially designed Applicator producing a low energy ultrasound-generated mist.

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This Ultrasound Technology Based UltraMist system accelerates healing through cleansing and maintenance debridement by the removal of fibrin, yellow slough, tissue exudates, and bacteria while promoting the production of collagen by compressing and stretching cell membranes. UltraMist also promotes regeneration and vasodilation increasing Oxygen to the cells stimulating the damaged areas and creating Angiogenesis.

Low intensity pulsed ultrasound accelerates macrophages that release growth factors including VegF and PGDF or Platelet Derived Growth Factors. VegF is essential to healthy blood flow and regulation of nutrients to skin and hair follicles. Similar to PRP but “without painful needles,” PGDF or Platelet Derived Growth Factors enhance the removal of damaged tissue by increasing Neutrophil counts. Neutrophils remove bacterial and fungal pathogens through a process known as phagocytosis.

UltraMist also lyses the Bacterial Cell Wall on skin surfaces resulting in a reduction of bacteria that can interfere with the healing process.

Administered by trained healthcare personnel to thousands of patients for more than a decade and supported by a vast array of clinical evidence, the UltraMIST System’s Ultrasound therapy promotes healing by controlling inflammation and reducing bacteria while increasing angiogenesis. Further, to promote healing, it increases perfusion through vasodilation, ultimately increasing oxygen and nutrients to the tissue.

THE PURE FEELING OF HEALING

The Pure® Product Overview

TopDocRX, the global leader in regenerative medicine, is proud to introduce and be the exclusive distributor of the Ultramist® product, a clinical grade ultrasound healing machine.

PURE PRODUCT® - PURE PRO® & PURE®

FDA Approved

After years of achieving the highest levels of scientific research and development, we have succeeded in acquiring FDA approval for UltraMIST.

REJUVENATE & REGENERATE FROM THE INSIDE OUT

Engineered to be the cleanest, most effective cellular regeneration healing product on the market.

Experience healing faster than ever before possible.

MEASURABLE & REPEATABLE RESULTS

Quantifying the qualities and characteristics of the PURE Products®

Tested on thousands of patients and FDA approved, UltraMIST just works… over and over again.

━ How UltraMIST Works

In action, the UltraMIST System mechanically removes barriers and promotes healing in a wide range of wound types. Indications include, but are not limited to, diabetic foot ulcers, venous leg ulcers, pressure ulcers, and surgical, burn, and deep tissue injuries. It also reduces and removes a wide range of bacteria, including biofilms, while preserving healthy structures.

━ How UltraMIST Works

In action, the UltraMIST System mechanically removes barriers and promotes healing in a wide range of wound types. Indications include, but are not limited to, diabetic foot ulcers, venous leg ulcers, pressure ulcers, and surgical, burn, and deep tissue injuries. It also reduces and removes a wide range of bacteria, including biofilms, while preserving healthy structures.

━ Key Benefits of UltraMIST Therapy

Reduces a Wide Range of Bacteria Including VRE, MRSA, Acinetobacter, and E. coli 1-3
High levels of bacteria in wounds delay healing. Mechanical stress caused by low frequency and noncontact ultrasound acoustic wave therapy result in bacterial cell death1 and reduction of bacterial count, even in highly colonized stage 3 pressure ulcers.2
Disrupts Bacterial Biofilms
Bacterial biofilm is a structured community of bacteria tightly enclosed within a self-produced exopolymeric matrix, and its presence is a significant barrier to wound or tissue healing. Since bacterial biofilm is metabolically inactive, it is extremely hard to disrupt with topical/systemic antibiotics, antimicrobials, and/or antiseptics. In a Boston University study, MIST* System treatments every day for six days dramatically reduced density of bacteria entrapped in the biofilm on an established rabbit ear biofilm model infected with Pseudomonas aeruginosa.4
*Data was compiled utilizing MIST System Therapy. The UltraMIST System is the successor, but maintains the same mechanism of action. For more, see our clinical summary.
Controls Inflammation
Bacterial biofilm is a structured community of bacteria tightly enclosed within a self-produced exopolymeric matrix, and its presence is a significant barrier to wound or tissue healing. Since bacterial biofilm is metabolically inactive, it is extremely hard to disrupt with topical/systemic antibiotics, antimicrobials, and/or antiseptics. In a Boston University study, MIST* System treatments every day for six days dramatically reduced density of bacteria entrapped in the biofilm on an established rabbit ear biofilm model infected with Pseudomonas aeruginosa.4
*Data was compiled utilizing MIST System Therapy. The UltraMIST System is the successor, but maintains the same mechanism of action. For more, see our clinical summary.
Improves Vasodilation
Adequate perfusion and vasodilation are required to promote wound and tissue healing. In a Mayo Clinic study5, MIST System treatments improved perfusion to the wound bed that promotes wound healing. Blood flow is especially crucial in deep tissue pressure injuries (DTPI). A retrospective study of DPTIs7 found 80% did not progress beyond stage 2 with the UltraMIST System combined with standard of care (SOC) versus 22% with SOC alone.

━ References

01

Kavros SJ, Schenck EC. Use of noncontact low-frequency ultrasound in the treatment of chronic foot and leg ulcerations: a 51 patient analysis. J Am Podiatr Med Assoc. 2007;97(2):95-101.

02

Serena T, Lee SK, Lam K, Attar P, Meneses P, Ennis W. The impact of noncontact, nonthermal, low-frequency ultrasound on bacterial counts in experimental and chronic wounds. Ostomy Wound Manage. 2009;55(1):22-30.

03

Kavros SJ, Wagner SA, Wennberg PW, Cockerill FR. The effect of ultrasound mist transfer technology on virulent bacterial wound pathogens. Abstract. Presented at SAWC 2002.

04

Seth AK, Mustoe TA, Galiano et al. Noncontact, low-frequency ultrasound as an effective therapy against Pseudomonas aeruginosa-infected biofilm wounds. Wound Repair Regen. 2013;21(2):266-274.

05

Liedl DA, Kavros SJ. The effect of mist ultra-sound transport technology on cutaneous microcirculatory blood flow. Abstract. SAWC, 2001.

06

Honaker J, Forston M. Adjunctive use of noncontact low-frequency ultrasound for treatment of suspected deep tissue injury: a case series. J Wound Ostomy Continence Nurs. 2011;38(4):394-403.

07

Honaker JS, Forston MR, Davis EA, Wiesner MM, Morgan JA. Effects of noncontact low-frequency ultrasound on healing of suspected deep tissue injury: A retrospective analysis. Int Wound J. 2013;10(1):65-72.

08

Thawer HA, Houghton PE. Effects of ultrasound delivered through a mist of saline to wounds in mice with diabetes mellitus. J Wound Care. 2004;13(5):1-6.

09

Yao M, Hasturk H, Kantarci A, et al. A pilot study evaluating noncontact low frequency ultrasound and underlying molecular mechanism on diabetic foot ulcers. Int Wound J. 2014;11(6):586-593.

━ Experience the true feeling of healing potentials.

Of the hundred trillion cells that make up the human body, stem cells are the most important. They are among the few cells in the body that have the potential to become a particular cell type and replace worn and damaged cells. We welcome you to contact us and learn how UltraMIST can help you and your patients.

Call us at 1-855-904-1047 or complete this form: